| 目錄号 | MZ0701-5MG | 售價 | 318.00元 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 規格 | 5mg | 運輸溫度 | 室溫運輸 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 其他名稱 | Flagecidin; Wuningmeisu C; NSC76712; AI350846; 回香黴素； | 保存溫度 | 2-8ºC幹燥保存，或置于-20ºC長(cháng)期幹燥保存！ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CAS号 | 22862-76-6 | 有效期 | 2年(nián) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 應用 | 抗生(shēng)素；JNK激活劑 | 訂購數量 |
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産品簡介: Anisomycin 茴香黴素
搜索關鍵詞： Anisomycin茴香黴素；Flagecidin；Protein synthesis inhibitor蛋白(bái)合成抑制劑；JNK activator JNK激活劑；SP600125；CAS NO：22862-76-6；
産品訂購：更大包裝或産品技(jì)術(shù)問題，請來電(diàn)/在線咨詢，電(diàn)話：021-54736159 。
産品描述： 茴香黴素（Anisomycin），來源于灰色鏈黴菌（Streptomyces griseolus）的吡咯烷抗生(shēng)素，是一(yī)種有效的蛋白(bái)合成抑制劑，通(tōng)過抑制真核生(shēng)物(wù)核糖體的肽酰轉移酶活性來發揮作用。據報(bào)道能(néng)誘導許多(duō)細胞的凋亡發生(shēng)，包括早幼粒細胞白(bái)血病細胞、Jurkat細胞、心室肌細胞和結腸腺癌細胞。啓動胞内信号和立早基因誘導。 茴香黴素是強效的JNK激活劑，活化MAP激酶（JNK/SAPK和p38/RK）。作為(wèi)一(yī)種有效的信号通(tōng)路(lù)激動劑，選擇性引發即刻早期基因誘導的同源性脫敏（c-fos，fosB，c-jun，junB和junD）。茴香黴素（30mg/kg）表現出優于環孢黴素A（MZ2501-10MG）的免疫抑制活性，阻斷皮膚移植小(xiǎo)鼠的T細胞增殖。
産品特性
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濃度 |
1mg |
5 mg |
10mg |
|
1mM |
3.7693 mL |
18.8466 mL |
37.6932 mL |
|
5mM |
0.7539mL |
3.7693 mL |
7.5386 mL |
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10mM |
0.3769 mL |
1.8847 mL |
3.7693 mL |
|
50mM |
0.0754 mL |
0.3769 mL |
0.7539mL |
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文獻1，Yan J et al. c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias. Cardiovasc Res. 2013 Mar 1;97(3):589-97. PMID: 23241357 體外研究（細胞實驗）： 細胞類型（Cell types）：Mouse atrial myocyte line (HL-1) 實驗方法（Assay）：Atrial myocytes were treated with 50 ng/mL anisomycin with or without 2 µmol/L SP600125, or a corresponding amount of the DMSO solvent for 16 or 24 h followed by biochemical or optical mapping studies. 體内研究（動物(wù)模型）： 動物(wù)模型（Animal Model）：Young (6 months) and aged (54 months) male New Zealand White rabbits 實驗方法（Assay）：LA effective refractory period (AERP) was measured using an S1-S2 pacing protocol and atrial arrhythmias (AT/AF) were induced using burst pacing in open-chest heartsin young rabbits with (n = 4) or without (n = 5)anisomycin treatment (15 mg/kg, iv, four treatments over 9 days)and aged rabbits without anisomycin treatment (n = 6). |
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文獻2，Lattal KM et al. Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4667-72. PMID: 15070775 體内研究（動物(wù)模型）： 動物(wù)模型（Animal Model）：Male C57BL/6 mice (8-12 weeks old) 配制方法（Formulation）：Anisomycin wasdiluted in salineand dissolved in 1 M HCl. The pH was adjusted to≈7 with 1 M NaOH. 實驗方法（Assay）：Mice received subcutaneous injections of 50 or 75 mg of anisomycin/kg of body weight or an equivalent volume of saline in the first experiment. Injections in all other experiments were 50 mg/kg of anisomycin or an equivalent volume of saline. |
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文獻3，Guo Xet al. GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway. Elife. 2016 Mar 14;5:e11903.PMID: 26974342. 體内研究（動物(wù)模型）： 動物(wù)模型（Animal Model）： 配制方法（Formulation）：Anisomycin was dissolved inDMSO to prepare a stock solution anddiluted inPBS before each administration. 實驗方法（Assay）：Anisomycin (30 mg/kg body weight)or vehicle was injected subcutaneously daily after optic nerve crush. To inhibit OPP incorporation, anisomycin (50 μg/ml) was injected intravitreally 1 hr before and together with OPP administration. |
相(xiàng)關産品：更大包裝或産品技(jì)術(shù)問題，請來電(diàn)/在線咨詢，電(diàn)話：021-54736159 。
|
貨号 |
産品名稱 |
規格 |
|
MZ0701-5MG |
Anisomycin 茴香黴素 |
5mg |
|
MZ0702-10MG |
SP600125 JNK抑制劑 |
10mg |
|
MZ0201-10MG |
Rapamycin (Sirolimus) 雷帕黴素（西(xī)羅莫司） |
10mg |
|
MZ2501-10MG |
Cyclosporin A (CsA) 環孢黴素A |
10mg |
注意事(shì)項
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