産品簡介:
Dehydroepiandrosterone Sulfate (DHEAS) Sodium Salt
去氫表雄酮硫酸鈉
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産品關鍵詞
DHEAS; Dehydroepiandrosterone (DHEA)去氫表雄酮;Androstenolone sulfate 雄甾烯二酮;GABAA受體調節劑;Neurosteroid神經類固醇;CAS NO:1099-87-2;
産品信息
産品名稱
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産品編号
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規格
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價格(元)
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Dehydroepiandrosterone Sulfate (DHEAS) Sodium Salt去氫表雄酮硫酸鈉
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MZ10051-50MG
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50mg
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399
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MZ10051-100MG
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100mg
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689
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MZ10051-1G
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1g
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3429
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産品描述
去氫表雄酮硫酸鈉(Dehydroepiandrosterone Sulfate Sodium Salt, DHEAS)是去氫表雄酮(DHEA)的代謝物(wù),後者是腎上(shàng)腺的主要分泌物(wù)和人體用于合成活性類固醇激素(甾體激素)的主導循環前體。青少年(nián)體内DHEAS正常的循環濃度約10µM,某些腎上(shàng)腺素皮質紊亂會(huì)急劇增高(gāo)。
産品特性
1)CAS NO:1099-87-2
2)化學名:sodium (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17- tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl sulfate
3)同義名:Dehydroepiandrosterone Sulfate (sodium salt); DHEAS; DHA-S; NSC 72822; Sodium prasterone sulfate; Dehydroepiandrosterone-3-sulfate Sodium Salt; Sodium Dehydroepiandrosterone-3-sulfate; 脫氫表雄酮硫酸鈉;硫酸普拉酮鈉;硫酸普拉睾酮鈉;脫氫表雄甾酮-3-硫酸鈉;
4)分子式:C19H27NaO5S
5) 分子量:390.47 g/mol
6) 外觀:白(bái)色至類白(bái)色粉末
7) 純度:≥98%
8) 溶解性:溶于乙醇(~2mg/ml)、DMSO(~30mg/ml)、DMF(~30mg/ml)
9) 化學結構式:
保存與運輸方法
保存:2-8℃幹燥保存,2年(nián)有效;-20℃幹燥保存,3年(nián)有效。
運輸:常溫運輸。
注意事(shì)項
1)本品不是臨床藥物(wù),隻能(néng)用于科研用途,不能(néng)用于診斷或臨床用途。
2)為(wèi)了您的安全和健康,請穿實驗服并戴一(yī)次性手套操作。
儲存液制備
使用方法【源自(zì)文獻,僅作參考】
文獻1,Yoon SY et al. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABAA receptors. Br J Pharmacol. 2009 Jun;157(4):666-73.PMID: 19422393
體内研究(動物(wù)模型):
動物(wù)模型(Animal Model):Male ICR mice (24–30 g)
藥物(wù)配制(Preparation):DHEA and progesterone were diluted in 1% DMSO in corn oil. DHEAS was diluted in 1% DMSO in saline.
給藥劑量(Dosage):Drugs were dissolved in 5 µL of vehicle.Intrathecal injections (5 µL volume) were made into the L5-L6 intervertebral space of unanaesthetized mice using a 10 µL Hamilton syringe connected to a 30-gauge needle. The control group received an i.t. injection of vehicle.
目的與結果(Results):To study the effect of DHEASand DHEAon the nociceptive threshold to mechanical stimulation.i.t. injection of DHEAS (150, 300 or 600 pmol) dose-dependently decreased withdrawal threshold to mechanical stimulation compared with that of the vehicle control group. Conversely,i.t. injection of DHEA (0.1, 10 and 1000 nmol per mouse)had no effect on the mechanical nociceptive threshold, even at the highest dose.
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Dehydroepiandrosterone (DHEA)去氫表雄酮
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MZ10051-50MG
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Dehydroepiandrosterone Sulfate (DHEAS) Sodium Salt去氫表雄酮硫酸鈉
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50mg
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— —Written/Edited by V. Shallan【版權歸MKBio懋康所有】
上海夢澤生物科技有限公司是一(yī)家涉足于生(shēng)命科學和生(shēng)物(wù)技(jì)術(shù)領域研究的試劑、儀器(qì)和實驗室消耗品與實驗服務工(gōng)作,主要從(cóng)事(shì)細胞生(shēng)物(wù)學、植物(wù)學、分子生(shēng)物(wù)學、免疫學、生(shēng)物(wù)化學、蛋白(bái)組學。生(shēng)物(wù)制藥與診斷試劑研發生(shēng)産等領域。 本公司秉承“以人為(wèi)本,以誠為(wèi)信、合同守信”的經營理念。堅持"品質保障"的原則為(wèi)廣大客戶提供優質産品。
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