目錄号 | MZ3403-25G | 售價 | 680.00元 | ||||||||||||||||||||||||||||||||||||||
規格 | 25g | 運輸溫度 | 室溫運輸 | ||||||||||||||||||||||||||||||||||||||
其他名稱 | Metformin HCl; 1,1-Dimethylbiguanide hydrochloride; | 保存溫度 | 室溫幹燥保存,或置于-20℃長(cháng)期幹燥保存 | ||||||||||||||||||||||||||||||||||||||
CAS号 | 1115-70-4 | 有效期 | 至少2年(nián) | ||||||||||||||||||||||||||||||||||||||
應用 | II型糖尿病治療藥物(wù)之一(yī) | 訂購數量 |
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産品簡介: Metformin Hydrochloride 鹽酸二甲雙胍
産品關鍵詞: Metformin HCl 鹽酸二甲雙胍;Acarbose 阿卡波糖;Antidiabetic drug抗糖尿病藥物(wù);Streptozotocin (STZ) 鏈脲佐菌素;CAS:1115-70-4;
産品信息
【溫馨提示】:見(jiàn)我司(MKBio)的小(xiǎo)分子化合物(wù)常見(jiàn)問題-懋康生(shēng)物(wù)。 【溫馨提示】:見(jiàn)我司(MKBio)整理的糖尿病模型建立-鏈脲佐菌素(STZ)。
産品描述 鹽酸二甲雙胍(Metformin Hydrochloride)是最有效和普遍使用的II型糖尿病治療藥物(wù)之一(yī),能(néng)夠降低(dī)肝細胞中高(gāo)血糖症,主要通(tōng)過抑制肝糖原的産生(shēng)(肝髒糖異生(shēng)作用)發揮作用。二甲雙胍(500μM)激活肝細胞AMPK,導緻乙酰輔酶A羧化酶(ACC)活性下(xià)降,誘導脂肪酸氧化,抑制脂肪生(shēng)成酶表達。二甲雙胍(2mM)激活肌肉AMPK,促進葡萄糖攝取。二甲雙胍降低(dī)肝髒葡萄糖生(shēng)成,增加肌肉細胞葡萄糖攝取[1]。二甲雙胍需要肝髒中的LKB1降低(dī)血糖濃度。二甲雙胍(250mg/kg,腹腔注射)以LKB1依賴的方式增加正常飲食小(xiǎo)鼠的肝髒AMPK活性以及降低(dī)高(gāo)脂飲食小(xiǎo)鼠内的血糖水(shuǐ)平超過50%。還(hái)能(néng)減低(dī)ob/ob小(xiǎo)鼠40%的血糖[2]。飲食誘導肥胖症的小(xiǎo)鼠注射二甲雙胍(10mg/kg/天或50mg/kg/天),能(néng)夠降低(dī)體重增加、肝髒脂滴含量,和血漿中總的膽固醇、LDL-膽固醇和甘油三酯水(shuǐ)平[3]。二甲雙胍(250mg/kg)能(néng)夠減少HCT116 p53-\-人結腸癌小(xiǎo)鼠移植瘤模型中的腫瘤生(shēng)長(cháng),但對過表達重組釀酒酵母Ndi NADH脫氫酶的HCT116 p53-\-腫瘤沒效應[4]。
産品特性 1) CAS NO:1115-70-4 2) 化學名:N,N-Dimethylimidodicarbonimidic diamide hydrochloride 3) 同義名:Metformin HCl; 1,1-Dimethylbiguanide hydrochloride; 4) 分子式:C4H12ClN5 5) 分子量:165.62 6) 純度:>98% 7) 外觀:白(bái)色結晶或結晶性粉末 8) 溶解性:溶于水(shuǐ)(100mM)、DMSO(50mM) 9) 化學結構式:
保存與運輸方法 保存:室溫幹燥保存,或置于-20℃長(cháng)期幹燥保存,至少2年(nián)有效。 運輸:室溫運輸。
注意事(shì)項 1) 本品并非商業(yè)化的臨床藥物(wù),僅用作科研用途,不得用作臨床診斷或治療,不得用于食品或藥品,絕對禁止用在人身上(shàng)。 2) 為(wèi)了您的安全和健康,請穿實驗服并戴一(yī)次性手套操作。
配制儲存液
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文獻1,Wheaton WW et al. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife. 2014 May 13;3:e02242. PMID: 24843020 體内研究: 動物(wù)模型(Animal Model):Female J:Nu mice 給藥劑量(Dosages):Female J:Nu mice were injected with 3 × 106Control-HCT 116 p53−/−or NDI1-HCT 116 p53−/−using a 27-gauge needle. 4 days post-injection mice were treated with water supplemented with metformin or water alone and fluid intake was monitored daily to ensure an effective dose of 1.25 mg/ml or 250 mg/kg of metformin. |
文獻2,Abdulreda MH et al.Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model. Cell Metab. 2016 Mar 8;23(3):541-6. PMID: 26876561 體内研究: 動物(wù)模型(Animal Model):C57BL/6 male mice fed a diet containing 60 kcal fat-derived calories 藥物(wù)配制(Preparation):Metformin, dissolved in saline, was orally administered daily for 14 weeks. 注射劑量(Dosages):Metformin was administered at a dose of 10 mg/kg or 50 mg/kg. The control mice were administered with saline. |
參考文獻
[1] Zhou G et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct;108(8):1167-74.
[2] Shaw RJ et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005 Dec 9;310(5754):1642-6.
[3] Kim EK et al. Metformin prevents fatty liver and improves balance of white/brown adipose in an obesity mouse model by inducing FGF21. Mediators Inflamm. 2016; 2016:5813030.
[4] Wheaton WW et al. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife. 2014 May 13;3:e02242.
— —Written/Edited by V. Shallan【版權歸MKBio懋康所有】
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