Fluorescein labeled Lycopersicon Esculentum (Tomato) Lectin (LEL, TL)

綠色熒光(guāng)标記番茄凝集素

産品标簽

番茄凝集素（Tomato lectin）；FITC-LEL；Intravascular perfusion血管内灌注；Lectin perfusion 凝集素灌注；Microvasculature 微血管；Endothelial cells 内皮細胞；

産品信息【原裝正品，現貨供應，大量引用文獻支持】

【溫馨提示】：見(jiàn)我司（懋康生(shēng)物(wù)）整理的Vector Labs血管功能(néng)研究-番茄凝集素産品專題。

産品描述

番茄凝集素（Tomato lectin，Lycopersicon Esculentum Lectin（LEL）），是一(yī)種非常穩定的單亞基糖蛋白(bái)，約含有等量的蛋白(bái)質和碳水(shuǐ)化合物(wù)。據報(bào)道其糖類部分由85%阿拉伯糖和15%半乳糖組成，在溶液中可能(néng)形成多(duō)聚體聚合物(wù)。番茄凝集素雖然和土(tǔ)豆凝集素、曼陀羅凝集素（DSL）和麥胚凝集素（WGA）有部分相(xiàng)同的特異性，但在許多(duō)多(duō)面呈現出獨特之處。番茄凝集素LEL能(néng)夠很好地與血型糖蛋白(bái)（glycophorin）和Tamm-Horsfall糖蛋白(bái)結合，能(néng)夠有效結合和标記齧齒類動物(wù)的血管内皮（vascular endothelium）。

本品為(wèi)綠色熒光(guāng)素标記的番茄凝集素（來源于Lycopersicon esculentum），Ex/Em=495/515nm，通(tōng)過血管内灌注法或直接染色組織切片能(néng)快速且有效的檢測和可視化齧齒類動物(wù)的血管和小(xiǎo)膠質細胞。

産品特征

相(xiàng)關産品：

引用文獻【Vector Labs】

Huang J et al. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7785-90. PMID: 12805568【Vascular lectin perfusion, 100 μg in 100 μl of saline, fluorescein- labeled Lycopersicon esculentum lectin, Vector Lab】

Inai T et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol. 2004 Jul;165(1):35-52. PMID: 15215160【Vascular lectin perfusion, 100 μg in 100 μl of 0.9% NaCl, fluorescein- labeled Lycopersicon esculentum lectin, Vector Lab】

Thurston, G., et al., Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice. J. Clin Invest, 1998. 101 (7): p. 1401-1413. PMID: 9525983

Hashizume, H., et al., Openings between defective endothelial cells explain tumor vessel leakiness. Amer J Pathol, 2000. 156(4): p. 1363-1380. PMID: 10751361.【Vascular perfusion, biotin- or fluorescein isothiocyanate (FITC)-labeled Lycopersicon esculentum lectin, 100 μg in 100 μl 0.9% NaCl, Vector Laboratories】   

Debbage, P.L., et al., Intravital lectin perfusion analysis of vascular permeability in human micro- and macro- blood vessels. Histochemistry Cell Biol, 2001. 116(4): p. 349-359.   

Lee, J.C., et al., Interleukin-12 inhibits angiogenesis and growth of transplanted but not in situ mouse mammary tumor virus-induced mammary carcinomas. Cancer Res, 2002. 62(3): p. 747-755.   

Akerman, M.E., et al., Nanocrystal targeting in vivo. Proc Nat Acad Sci Usa, 2002. 99(20): p. 12617-12621.   

Gee, M.S., et al., Tumor vessel development and maturation impose limits on the effectiveness of anti-vascular therapy. Amer J Pathol, 2003. 162(1): p. 183-193.   

Jilani, S.M., et al., Selective binding of lectins to embryonic chicken vasculature. J Histochem Cytochem, 2003. 51(5): p. 597-604.   

Krasnici, S., et al., Effect of the surface charge of liposomes on their uptake by angiogenic tumor vessels. Int J Cancer, 2003. 105(4): p. 561-567.

 — —Written/Edited by V. Shallan【版權歸MKBio懋康所有】

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