産品簡介:
Paclitaxel紫杉醇
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産品标簽
Cisplatin順鉑;Oxaliplatin奧沙利鉑;DNA Crosslinker DNA交聯劑;Cyclophosphamide環磷酰胺;CAS:33069-62-4;
産品信息
産品名稱
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産品編号
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CAS NO.
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規格
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價格(元)
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Paclitaxel紫杉醇
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MZ5871-50MG
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33069-62-4
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50mg
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288
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Paclitaxel紫杉醇
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MZ5871-200MG
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33069-62-4
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200mg
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688
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Paclitaxel紫杉醇
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MZ5871-1G
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33069-62-4
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1g
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1588
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Paclitaxel紫杉醇
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MZ5871-5G
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33069-62-4
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5g
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3988
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産品描述
紫杉醇(Paclitaxel,Taxol),CAS NO.33069-62-4,一(yī)種抗腫瘤化合物(wù)和微管聚合物(wù)穩定劑。對一(yī)組腫瘤細胞包括宮頸癌(HeLa),肺癌(A549),乳腺癌(MCF-7),結腸癌(HT-29),卵巢癌(OVG-1)和胰髒癌(PC-Sh)細胞進行紫杉醇的細胞毒性測試,IC50s= 2.5-7.5 nM。各種癌細胞系中,紫杉醇破壞多(duō)極紡錘體形成,誘導細胞周期停滞在前期和G1期,IC50s= 6.7-18.5 nM。紫杉醇啓動癌細胞凋亡,通(tōng)過p53依賴和非依賴途徑,Bcl-2家族蛋白(bái),細胞周期蛋白(bái)依賴的激酶和JNK/SAPK參與的多(duō)種機(jī)制來發揮作用。紫杉醇是神經突起生(shēng)長(cháng)和啓動的一(yī)種抑制劑,通(tōng)過破壞生(shēng)長(cháng)中突起的微管組裝和移除細胞質的微管來發揮作用。紫杉醇是PKA和Raf-1的強效激活劑。
産品特性
1) CAS NO:33069-62-4
2) 化學名:βS-(benzoylamino)-αR-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS) -6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
3) 同義名:Taxol,NSC 125973
4) 分子式:C47H51NO14
5) 分子量:853.92
6) 純度:≥99%
7) 外觀:白(bái)色或類白(bái)色結晶性粉末
8) 溶解性:溶于DMSO(80mg/ml)、乙醇(10mg/ml),幾乎不溶于水(shuǐ)
9) 化學結構式:
保存與運輸方法
保存:2-8℃幹燥保存,也可置于-20ºC幹燥長(cháng)期保存,至少2年(nián)有效。
運輸:室溫運輸。
使用方法【源自(zì)文獻,僅作參考】
文獻1,Elzbieta Izbicka et al.Biomarkers for Sensitivity to Docetaxel and Paclitaxel in Human Tumor Cell Lines In Vitro.CANCER GENOMICS & PROTEOMICS 2: 219-226 (2005).
體外研究(細胞實驗):
細胞類型(Cell type):LNCaP prostate, SK-MES,MCF-7 and MDA-MB-231,MV-522 lung carcinoma cell lines
藥物(wù)濃度(Concentration):1000 pM for all cell lines in 3- and 5-day exposures, with the exception for500 pM paclitaxelin MDA-MB-231 for a 5-day treatment.A 10 mM stock solution of paclitaxel was prepared in 100% DMSO, and all dilutions contained 0.1% DMSO.
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文獻2,Park SJ et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3; 279(49): 51057-67.PMID: 15452117
體外研究(細胞實驗):
細胞類型(Cell type):CCRF-HSB-2 human T-cell lymphoblastic leukemia cell line
藥物(wù)濃度(Concentration):For MTT assay, 1 × 104 cells were plated in 100 μl of the growth medium in the presence or absence of increasing concentrations (0.1–1 μM) of taxolin 96-well plates and cultured at 37 °C in 5% CO2 for 12–48 h. The results revealed thattaxol at 0.1, 0.5, and 1 μM reduced the proliferation and survival of CCRF-HSB-2 cells in a dose-dependent fashion and that the IC50 value of taxol was about 0.25 μM.
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文獻3,Huehnchen P et al.Assessment of Paclitaxel Induced Sensory Polyneuropathy with “Catwalk” Automated Gait Analysis in Mice.PLoS One. 2013 Oct 15;8(10): e76772. PMID: 24143194
體内研究(動物(wù)模型):
動物(wù)模型(Animal Model):85 nine-week old male C57BL/6J mice
注射劑量(Dosages):20 mg PTX/kg BW,dissolved in Cremophor EL: Ethanol (1:1) with a concentration of 6 mg/ml and diluted in sterile 0.9% NaCl solution to a final concentration of 2 mg/ml before injection
給藥途徑(Administration):Intraperitoneal (i.p.) injection
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文獻4,Cadamuro M et al. Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma. Cancer Res. 2016 Aug 15;76(16):4775-84. PMID: 27328733
體内研究(動物(wù)模型):
動物(wù)模型(Animal Model):SCID mice xenotransplanted with human EGI-1 cells
注射劑量(Dosages):Once tumor engraftment was confirmed by bioluminescence imaging (time 0), we started metronomic infusion ofpaclitaxel [diluted in a 50%/50% solution of Cremophor EL and ethanol (vehicle)] for 2 weeks at the dosage of 2.6 mg/kg/day by intraperitoneal injection using micro-osmotic pumps.
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注意事(shì)項
1) 本品水(shuǐ)溶性非常差,可使用聚氧乙烯蓖麻油(Cremophor EL)和無水(shuǐ)乙醇(1:1)用作增溶劑。
2) 本品用于體内動物(wù)實驗,可使用溶劑5% DMSO+5% Tween 80+ddH2O依此加入來溶解粉末,濃度約2.5mg/ml;或者參考文獻結合給藥方式,選擇其他适當溶劑體系。
3) 本品不是臨床藥物(wù),隻能(néng)用于科研用途,不能(néng)用于診斷或臨床用途。
4) 為(wèi)了您的安全和健康,請穿實驗服并戴一(yī)次性手套操作。
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— —Written/Edited by V. Shallan【版權歸MKBio懋康所有】
上海夢澤生物科技有限公司是一(yī)家涉足于生(shēng)命科學和生(shēng)物(wù)技(jì)術(shù)領域研究的試劑、儀器(qì)和實驗室消耗品與實驗服務工(gōng)作,主要從(cóng)事(shì)細胞生(shēng)物(wù)學、植物(wù)學、分子生(shēng)物(wù)學、免疫學、生(shēng)物(wù)化學、蛋白(bái)組學。生(shēng)物(wù)制藥與診斷試劑研發生(shēng)産等領域。 本公司秉承“以人為(wèi)本,以誠為(wèi)信、合同守信”的經營理念。堅持"品質保障"的原則為(wèi)廣大客戶提供優質産品。
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