Stemolecule™ PD0325901（MEK抑制劑）

産品關鍵詞：

MEK；naïve stem cells 初始幹細胞；neural progenitor cells 神經祖細胞；WH-4-023；CHIR99021；CAS：391210-10-9；

産品描述：

PD0325901是一(yī)種靶向MAPK（MAPK/ERK kinase或MEK）的小(xiǎo)分子，具潛在的抗腫瘤活性。PD0325901是MEK抑制劑CI-1040的衍生(shēng)物(wù)，選擇性結合和抑制MEK，可能(néng)引起MAPK/ERK的磷酸化和活化，抑制腫瘤細胞增殖。與ALK5抑制劑SB431542一(yī)起，PD0325901能(néng)夠提高(gāo)人原代成纖維細胞重編程為(wèi)誘導多(duō)潛能(néng)幹細胞（iPS）的能(néng)力。

Stemgent公司提供支持初始潛能(néng)幹細胞應用需要的5i/L/A培養基添加劑（5i/L/A media supplment）所有成分，如下(xià)：

産品特性

1. 同義名：N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

2. 分子式：C16H14F3IN2O4

3. 分子量：482.19g/mol

4. CAS NO:391210-10-9

5. 純度：＞97%（HPLC）

6. 外觀：Pale purple solid

7. 溶解性：DMSO

8. 保存和穩定性：粉末4 °C避光(guāng)保存，重溶後的儲存液分裝後-20 °C保存，6個(gè)月(yuè)穩定。

9. 質量控制：HPLC測定純度，MS測定準确分子量，PD0325901對小(xiǎo)鼠胚胎幹細胞的細胞毒性測試。

10. 結構圖：

訂購信息：原裝正品，歡迎訂購，聯系電(diàn)話：021-54736159，QQ：2971634497。

引用文獻：

• Han Y-C, Lim Y; Duffieldl MD; Liu J; Manaph NPA; Yang M; Keating DJ; Zhou X-F. "Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules." Stem Cells International 2016:4304916 (2016)

• Liu G. "No detection of potential cancer risk for free-viral reprogrammed stem cell-derived dopaminergic neurons from adult mice fibroblasts." J Stem Cell Res Ther 5:286 (2015)

• Ren J; Briones V; Barbour S; Yu W; Han Y; Tarashima M; Muegge K. "The ATP binding site of the chromatin remodeling homolog LSH is required for nucleosome density and de novo DNA methylation at repeat sequences." Nucl Acids Res doi: 10.1093/nar/gku1371 (2015)

• DeRosa BA; Belle KC; Thomas BJ; Cukier HN; Pericak-Vance MA; Vance JM; Dykxhoom DM. "hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells." Mol Cell Neurosci 68:244 (2015)

• Ying, Q., Tai, C. Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. Journal of Cell Science 126, 1093 – 1098.(2013)

• Moraveji S-F; Attari F; Shahverdi A; Sepehri H; Farrokhi A; Hassani S; Fonoudi H; Aghdami N; Baharvand H. "Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis." Human Reproduction 27:2312 (2012)

• Chiang P-M; Wong PC. "Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: Essential role of bone morphogenetic protein 4." Development 138: 2833-2843 (2011)

• Nagy, K., Sung, H-K., Zhang, P., Laflamme, S., Vincent, P, Agha-Mohammadi, S., Woltjen, K., Monetti, C., Michael, I. P., Smith, L. C., Nagy, A. Induced Pluripotent Stem Cell Lines Derive from Equine Fibroblasts. Stem Cell Reviews and Reports 7:693 (2011).

• Wang, B., Miyagoe-Suzuki, Y., Yada, E., Ito, N., Nishiyama, T., Nakamura, M., Ono, Y., Motohashi, N., Segawa, M., Masuda, S., Takeda, S. Reprogramming Efficiency and Quality of Induced Pluripotent Stem Cells (iPSCs) Generated from Muscle-derived Fibroblasts of MDX Mice at Different Ages. PLOS Currents Muscular Dystrophy. 2011 Oct 27 . Edition 1. doi: 10.1371/currents.RRN1274 .

• Mack, A., Kroboth, S., Rajesh, D., Wang, W. B. Generation of Induced Pluripotent Stem Cells from CD34+ Cells across Blood Drawn from Multiple Donors with Non-Integrating Episomal Vectors. PLoS One; 6(11): e27956.(2011)

• Li, W., Zhou, H., Abujarour, R., Zhu, S., Young Joo, J., Lin, T., Hao, E., Schöler, H.R., Hayek, A., Ding, S. (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27: 2992-3000.

• Ying, Q.L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., and Smith, A. (2008) The ground state of embryonic stem cell self renewal. Nature 453: 519-523.

   

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