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當前位置: 首頁> 産品中心> 信号轉導研究相(xiàng)關 > 細胞代謝 > Deferiprone (DFP)去鐵​酮(鐵螯合劑)
Deferiprone (DFP)去鐵​酮(鐵螯合劑)
目錄号 MZ5276-1G 售價 233.00元
規格 1g 運輸溫度 冰袋運輸。
其他名稱 保存溫度 -20℃避光(guāng)幹燥保存,至少2年(nián)有效
CAS号 30652-11-0 有效期
應用 訂購數量
産品簡介:

Deferiprone (DFP)去鐵酮(鐵螯合劑)



産品關鍵詞:

Deferiprone (DFP)去鐵酮;Liproxstatin-1;Iron chelator鐵螯合劑;鐵死亡抑制劑;BCP-T.A.;(1S,3R)-RSL3;Ferroptosis inducer鐵死亡誘導劑;FeRhoNox-1 (Fe2+ indicator)亞鐵離子熒光(guāng)探針;C11 BODIPY 581/591;CAS:30652-11-0;



産品信息

産品名稱

産品編号

CAS NO.

規格

價格(元)

Deferiprone (DFP)去鐵酮(鐵螯合劑)

MZ5276-100MG

30652-11-0

100mg

97

Deferiprone (DFP)去鐵酮(鐵螯合劑)

MZ5276-1G

30652-11-0

1g

233

Deferiprone (DFP)去鐵酮(鐵螯合劑)

MZ5276-5G

30652-11-0

5g

583


産品描述

去鐵酮(Deferiprone, DFP)是一(yī)種鐵螯合劑,按照(zhào)3:1比例(配基:鐵離子)與鐵結合,具抗氧化劑和神經保護作用。DFP(100 µM)逆轉HT-1080纖維肉瘤細胞内愛拉斯汀誘導的鐵死亡,另外,DFP能(néng)降低(dī)原代大鼠肝細胞的胞内鐵水(shuǐ)平以及脂質過氧化,作用濃度分别是200 µM和50 µM。DFP(50mg/kg)能(néng)夠減低(dī)兔海馬内膽固醇飲食誘導的Aβ42和Aβ40增加,以及tau和GSK-3β磷酸化。


産品特性

CAS NO:30652-11-0

MDL NO:MFCD00134497

化學名:3-hydroxy-1,2-dimethyl-4(1H)-pyridinone

同義名:CGP 37391、DN 18001AF

分子式:C7H9NO2

分子量:139.15

外觀:白(bái)色至類白(bái)色固體

純度:≥98%

溶解性:溶于甲醇(5mg/ml)、H2O(≥3mg/ml,需要超聲或加熱助溶)

化學結構式:


保存與運輸方法

保存:-20℃避光(guāng)幹燥保存,至少2年(nián)有效。

運輸:冰袋運輸。


注意事(shì)項

1) 針對溶解性比較差的化合物(wù),可通(tōng)過37℃孵育以及超聲的方式來促進其溶解。

2) 本品并非商業(yè)化的臨床藥物(wù),僅用作科研用途,不得用作臨床診斷或治療,不得用于食品或藥品,絕對禁止用在人身上(shàng)。 

3) 為(wèi)了您的安全和健康,請穿實驗服并戴一(yī)次性手套操作。


儲存液制備

          質量

溶劑體積

濃度

1mg

5mg

10mg

1mM

7.1865 mL

35.9324 mL

71.8649 mL

5mM

1.4373 mL

7.1865 mL

14.3730 mL

10mM

0.7186 mL

3.5932 mL

7.1865 mL

【溫馨提示】:請根據産品在不同溶劑中的溶解度選擇合适的溶劑配制儲備液;一(yī)旦配成溶液,請分裝保存,避免反複凍融造成的産品失效。儲備液置于-80°C保存,約6個(gè)月(yuè)有效;-20°C保存,約1個(gè)月(yuè)有效。溶液儲存的過程中避免強光(guāng)直射。


使用方法【源自(zì)文獻,僅作參考】

文獻1,Liu, R.-Z.; Zhang, S.; Zhang, W.; Zhao, X.-Y.; Du, G.-H. Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats. Antioxidants 2023, 12, 12. https://doi.org/10.3390/antiox12010012


體内研究(動物(wù)模型):

動物(wù)模型(Animal Model):Male SD rats

實驗方法(Assay):The rats were randomly divided into 5 groups: the control group, model group, BAI-300 group, BAI-150 group, and DFP-150 group. All of the groups received an intraperitoneal injection of 2.5 mg/kg rotenone q.d. for 6 weeks, except for the control group, which received an equal volume of vehicle. From the third week to the sixth week, the rats were administered 300 mg/kg of baicalein (BAI-300 group), 150 mg/kg baicalein (BAI-150 group), or 150 mg/kg of deferiprone (DFP-150 group) q.d. by gavage, while the control group and the model group received an equal volume of vehicle. The dose of baicalein was determined based on a previous study;the dose of deferiprone was based on its clinical trial (30 mg/kg/d) and preclinical studies.

文獻2,Fiorillo, M.; Tóth, F.; Brindisi, M.; Sotgia, F.; Lisanti, M.P. Deferiprone (DFP) Targets Cancer Stem Cell (CSC) Propagation by Inhibiting Mitochondrial Metabolism and Inducing ROS Production. Cells 2020, 9, 1529. https://doi.org/10.3390/cells9061529


體外研究(細胞水(shuǐ)平):

細胞類型(Cell Type):MCF7 cells

實驗方法(Assay):To evaluate the mitochondrial superoxide production, a MitoSOX probe was used.The MCF7 cells were treated with DFP (1 μM to 1000 μM) for 24 to 120 h. The vehicle alone (DMSO) control cells were processed in parallel.After 48 h, the cells were washed with PBS and incubated with MitoSOX (diluted in PBS/CM to a final concentration of 5 μM) for 10 min at 37 °C


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