産品簡介:
Decylubiquinone
癸基泛醌
産品标簽
Decylubiquinone癸基泛醌；米酵菌酸（Bongkrekic Acid, BA）；Coenzyme Q10輔酶Q10；Mitochondrial permeability transition pore (MPTP)；活性氧生(shēng)成抑制劑ROSproduction inhibitor；CAS：55486-00-5；
産品信息
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産品名稱
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産品編号
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規格
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價格（元）
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Decylubiquinone癸基泛醌
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MX3266-5MG
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5mg
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523
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Decylubiquinone癸基泛醌
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MX3266-10MG
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10mg
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993
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Decylubiquinone癸基泛醌
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MX3266-50MG
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50mg
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4093
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産品描述
癸基泛醌（Decylubiquinone）是泛醌（輔酶Q10）的結構類似物(wù)。能(néng)夠阻斷谷胱甘肽耗竭應激引起的活性氧（ROS）生(shēng)成，以及抑制線粒體膜通(tōng)透性轉換的活化。癸基泛醌能(néng)抑制Ca2+依賴性的線粒體膜通(tōng)透性轉化孔（MPTP）的開(kāi)放(fàng)，不會(huì)幹擾呼吸作用。L929細胞内，通(tōng)過抑制細胞色素c的釋放(fàng)，癸基泛醌（5μM）抑制依托泊苷（MX3256-100MG）誘導的凋亡。在發育和心血管功能(néng)研究的斑馬魚模型中，延緩魚藤酮誘導的心功能(néng)障礙。能(néng)用作各種醌氧化還(hái)原酶的底物(wù)。
産品特性
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化學名：2-Decyl-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
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CAS NO：55486-00-5
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同義名：2,3-Dmdb
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分子式：C19H30O4
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分子量：322.44
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純度：≥98%
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外觀：乙醇溶液（濃度見(jiàn)标簽）
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化學結構式：
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保存與運輸方法
保存：-20℃幹燥保存，2年(nián)有效。
運輸：室溫運輸。
注意事(shì)項
1） 本品并非商業(yè)化的臨床藥物(wù)，僅用作科研用途，不得用作臨床診斷或治療，不得用于食品或藥品，絕對禁止用在人身上(shàng)。
2） 為(wèi)了您的安全和健康，請穿實驗服并戴一(yī)次性手套操作。
使用方法【源自(zì)文獻，僅作參考】
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文獻1，Telford JE, Kilbride SM, Davey GP. Decylubiquinone increases mitochondrial function in synaptosomes. J Biol Chem. 2010 Mar 19;285(12):8639-45. doi: 10.1074/jbc.M109.079780. Epub 2010 Jan 14. PMID: 20080966; PMCID: PMC2838286.
體外研究（In Vitro Assay）：
樣本類型（Sample type）：Synaptosomes
實驗方法（ETC Assays）： The stored synaptosomal samples were freeze-fractured three times by rapid freezing in liquid nitrogen followed by thawing at 37 °C in a water bath. The complex activities of the samples were determined on a Cary UV spectrophotometer at 37 °C. Reaction buffer (10 mm MgCl2 and 25 mm potassium phosphate, pH 7.2), 0.2 mm NADH, 2.5 mg of bovine serum albumin, 1 mm KCN, and 100 μg of synaptosomes were added to plastic cuvettes with a final volume of 1 ml. Decylubiquinone (50 μM) was used to initiate the reaction, and the rates were recorded for 7–8 min. To determine the rotenone-insensitive rates, rotenone (10 μm) was added to the cuvettes, and the rates were monitored for a further 5–6 min.
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文獻2，Li J, Zheng S, Cheng T, Li Y, Mai X, Jiang G, Yang Y, Zhang Q, Li J, Zheng L, Wang L, Qi C. Decylubiquinone Inhibits Colorectal Cancer Growth Through Upregulating Sirtuin2. Front Pharmacol. 2022 Feb 1;12:804265. doi: 10.3389/fphar.2021.804265. PMID: 35177983; PMCID: PMC8844026.
體外研究（In Vitro Assay）：
細胞類型（Cell type）： CRC cells (HCT116 and LoVo cells)
實驗方法（Cell viabilityassay）： CRC cells (1.0×103cells/well) were seeded in 96-well plates andtreated with different concentrations of Dub (0, 15, 30, 45, 60, 75, 90, 105 μM), and control cells were treated with DMSO. After 96 h of DUb treatment, MTT was added to measure cell viability. Half maximal inhibitory concentration (IC50) values were calculated from the inhibitory curves. The IC50 values of DUb were calculated to be 45.84 µM for HCT116 cells and 28.11 µM for LoVo cells.
體内研究（In Vivo Assay）：
動物(wù)模型（Animal Model）：6-week-old athymic nude mice
實驗方法（Assay）：Athymic nude mice were intraperitoneally treatedwith DUb (5 mg/kg, three times per week for 3 weeks) or DMSO for 54 days.CT26 CRC cell line was injected subcutaneously into the flanks of 6-8-week-old BALB/c mice. CT26 xenograft mice were treated intraperitoneally with DUb (5 mg/kg) or DMSO every day since the tumor could be observed with the naked eye for 12 days. The body weights of mice were weighed during DUb or DMSO treatment.
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— —Written/Edited by V. Shallan【版權歸MKBio懋康所有】
上海夢澤生物科技有限公司是一(yī)家涉足于生(shēng)命科學和生(shēng)物(wù)技(jì)術(shù)領域研究的試劑、儀器(qì)和實驗室消耗品與實驗服務工(gōng)作，主要從(cóng)事(shì)細胞生(shēng)物(wù)學、植物(wù)學、分子生(shēng)物(wù)學、免疫學、生(shēng)物(wù)化學、蛋白(bái)組學。生(shēng)物(wù)制藥與診斷試劑研發生(shēng)産等領域。 本公司秉承“以人為(wèi)本，以誠為(wèi)信、合同守信”的經營理念。堅持"品質保障"的原則為(wèi)廣大客戶提供優質産品。
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