産品名稱

産品編号

CAS NO.

規格

價格（元）

促銷價（元）

Semaglutide索馬魯肽

MZ7352-1MG

910463-68-2

1mg

1580

1422

Semaglutide索馬魯肽

MZ7352-5MG

910463-68-2

5mg

3980

3582

Semaglutide索馬魯肽

MZ7352-10MG

910463-68-2

10mg

5980

5382

          質量

溶劑體積

濃度

1mg

5mg

10mg

0.5mM

0.4862 mL

2.4310 mL

4.8619 mL

0.1mM

2.4310 mL

12.1549 mL

24.3097mL

文獻1，Rakipovski G, Rolin B, Nøhr J, Klewe I, Frederiksen KS, Augustin R, Hecksher-Sørensen J, Ingvorsen C, Polex-Wolf J, Knudsen LB. The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE-/- and LDLr-/- Mice by a Mechanism That Includes Inflammatory Pathways. JACC Basic Transl Sci. 2018 Nov 21;3(6):844-857. doi: 10.1016/j.jacbts.2018.09.004. PMID: 30623143; PMCID: PMC6314963.

體内研究（動物(wù)模型）：

動物(wù)模型（Animal Model）：C57BL/6J lean male mice at 12 weeks of age

實驗方法（Assay）：To studyacute inflammation in vivo study design, C57BL/6J lean male mice at 12 weeks of age were givenSC doses of semaglutide (60.0 μg/kg) or vehicle control 1 hour prior to receiving an IP dose of lipopolysaccharide (LPS) (0.05 mg/kg, Escherichia coli O55:B5) or vehicle control.Blood samples were collected from the sinus orbital vein at 1 and 4 h after LPS dose.

文獻2，Wang L, Ding J, Zhu C, Guo B, Yang W, He W, Li X, Wang Y, Li W, Wang F, Wang F, et al: Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice. Int J Mol Med 48: 219, 2021

體外研究：

細胞類型（Cell type）：BV2 cells

實驗方法（Assay）： BV2 cells were seeded into 96-well plates (1×104 cells/well) for 12 h, and thentreated with different doses (300, 600, 900 or 1,000 nM) of semaglutide for 20 h at 37°C. A blank well with culture medium was used to detect background, and five replicate wells were established per group. CCK-8 reagent (100 µl) was added toevaluate cellular proliferation.

體内研究（動物(wù)模型）：

動物(wù)模型（Animal Model）：C57BL/6J mice (male, 10±2 weeks old; weight, 25±3 g)

實驗方法（Assay）：The animals were randomized into five groups (20 per group), all of which were treated by intraperitoneal (i.p.) injection. In the control group (1% DMSO, i.p.), mice received 20 injections in total - 19 injections every other day for 37 days, and a final injection on the 45th day.For the semaglutide group [25 nM/kg semaglutide i.p.], the administration schedule was the same as that for the control group. In the PTZ group [37 mg/kg PTZ, i.p.], the mice received a total of 16 injections - one injection every other day from the 9th to the 37th day for a total of 15 injections, and a final injection on the 45th day.For the low-dose semaglutide group [37 mg/kg PTZ + 10 nM/kg semaglutide, i.p.], the semaglutide administration schedule was the same as that for the control group, and the PTZ administration schedule was the same as that for the PTZ group, 30 min after each injection of semaglutide.For the high-dose semaglutide group (37 mg/kg PTZ + 25 nM/kg semaglutide, i.p.), the administration schedule was the same as that for the low-dose semaglutide group.

貨号

名稱

規格

MZ7351-1MG

Liraglutide利拉魯肽

1mg

MZ7352-1MG

Semaglutide索馬魯肽

1mg

MZ3403-1G

Metformin Hydrochloride鹽酸二甲雙胍

1g

MZ99023-1G

Acarbose阿卡波糖

1g

MS1601-100MG

Streptozotocin (STZ)鏈脲佐菌素

100mg