| 目錄号 | MZ6402-50MG | 售價 | 922.00元 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 規格 | 50mg | 運輸溫度 | 冰袋運輸。 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 其他名稱 | 保存溫度 | -20ºC避光(guāng)幹燥保存，至少2年(nián)有效。 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CAS号 | 36913-39-0 | 有效期 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 應用 | 訂購數量 |
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産品簡介: MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide)
産品标簽 MPP+ iodide；MPTP；帕金森病動物(wù)模型；Ferroptosisinhibitor；Necrostatin-1；Ferrostatin-1 (Fer-1)；CAS：36913-39-0；
産品信息：
産品描述 MPP+iodide (N-Methyl-4-Phenylpyridinium Iodide)是神經毒素MPTP的活性代謝物(wù)，在帕金森病動物(wù)模型中選擇性破壞多(duō)巴胺能(néng)神經元。MPP+主要通(tōng)過抑制線粒體電(diàn)子傳遞鏈複合物(wù)I，引起ATP耗竭和氧化應激增高(gāo)，從(cóng)而誘導神經毒性。MPP+誘導Necrostatin-1 (Nec-1)和 Ferrostatin-1 (Fer-1)敏感的SH-SY5Y細胞壞死，但MPP+誘導的壞死性細胞死亡與鐵壞死是不同的生(shēng)理過程。
産品特性 1） 化學名：1-Methyl-4-phenylpyridin-1-ium iodide 2） 同義名：N-Methyl-4-Phenylpyridinium Iodide; 1-methyl-4-phenyl-pyridinium, monoiodide; MPP+;N-甲基-4-苯基吡啶鎓碘化物(wù)；1-甲基-4-苯基-吡啶鎓碘化物(wù)；1-甲基-4-苯基吡啶碘化物(wù)； 3） CAS NO：36913-39-0 4） 分子式：C12H12IN 5） 分子量：297.16） 純度：≥98%7） 外觀：固體8） 溶解性：溶于H2O（100mM）
9） 化學結構式：
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濃度 |
1mg |
5mg |
10mg |
|
1mM |
3.3654 mL |
16.8271 mL |
33.6542mL |
|
5mM |
0.6731mL |
3.3654 mL |
6.7308mL |
|
10mM |
0.3365 mL |
1.6827 mL |
3.3654 mL |
|
文獻1，Stahl K, Rahmani S, Prydz A, Skauli N, MacAulay N, Mylonakou MN, Torp R, Skare Ø, Berg T, Leergaard TB, Paulsen RE, Ottersen OP, Amiry-Moghaddam M. Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease. PLoS One. 2018 Mar 22;13(3):e0194896. doi: 10.1371/journal.pone.0194896. PMID: 29566083; PMCID: PMC5864064. 體内研究（動物(wù)模型）： 動物(wù)模型（Animal Model）：C57BL/6J WT and Aqp9-/- mice 配制方法（Formulation）：MPP+ (7.5 μg dissolved in saline) 實驗方法（Assay）：C57BL/6J WT (n = 34) and Aqp9-/- mice (n = 29) were deeply anesthetized with zoletil mixture, Rompunand Fentanyl and then subjected tostereotaxic intrastriatal injections of MPP+ (7.5 μg dissolved in saline) or saline. 1 μl MPP+ solution or saline was injected into the striatum 0.6 mm anterior to Bregma, 2.2 mm laterally and 3.2 mm ventrally at 12 μl/hr using a syringe pump. MPP+ was protected against light during the procedure. The injector was left for 5 minutes to allow diffusion before suture. |
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文獻2，Xu J, Gao X, Yang C, Chen L, Chen Z. Resolvin D1 Attenuates Mpp+-Induced Parkinson Disease via Inhibiting Inflammation in PC12 Cells. Med Sci Monit. 2017 Jun 2;23:2684-2691. doi: 10.12659/msm.901995. PMID: 28572562; PMCID: PMC5465971. 體外研究（細胞實驗）： 細胞類型（Cell types）：PC12 cells 實驗方法（Assay）：The in vitro PD model was established by treatment of PC12 cells with250 μM MPP+ for approximately 24 hours.Different concentrations of RvD1 (50, 100, 200 nM) were administrated two hours prior to MPP+ treatment, afterwards, PC12 cells were used for following experiments. |
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文獻3，Christensen C, Þorsteinsson H, Maier VH, Karlsson KÆ. Multi-parameter Behavioral Phenotyping of the MPP+ Model of Parkinson's Disease in Zebrafish. Front Behav Neurosci. 2020 Dec 18;14:623924. doi: 10.3389/fnbeh.2020.623924. PMID: 33390914; PMCID: PMC7775599. 體内研究（動物(wù)模型）： 動物(wù)模型（Animal Model）：Zebrafish larvae 配制方法（Formulation）：Both MPP+ and PBA were dissolved in the system water. 實驗方法（Assay）：Zebrafish larvae were incubated between 1 and 5 dpf in the presence or absence of 500 μM MPP+ at a total volume of 25 ml system water. The drug solutions were freshly prepared and replaced between 11:00 and 12:00 am at 2, 3, and 4 dpf.Deceased larvae were removed daily, but no differences in mortality were observed between MPP+ exposed larvae and untreated larvae. |
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— —Written/Edited by V. Shallan【版權歸MKBio懋康所有】
上海夢澤生物科技有限公司是一(yī)家涉足于生(shēng)命科學和生(shēng)物(wù)技(jì)術(shù)領域研究的試劑、儀器(qì)和實驗室消耗品與實驗服務工(gōng)作，主要從(cóng)事(shì)細胞生(shēng)物(wù)學、植物(wù)學、分子生(shēng)物(wù)學、免疫學、生(shēng)物(wù)化學、蛋白(bái)組學。生(shēng)物(wù)制藥與診斷試劑研發生(shēng)産等領域。 本公司秉承“以人為(wèi)本，以誠為(wèi)信、合同守信”的經營理念。堅持"品質保障"的原則為(wèi)廣大客戶提供優質産品。
